United States securities and exchange commission logo July 13, 2021 Keith Taylor Chief Financial Officer EQUINIX INC One Lagoon Drive Redwood City, CA 94065 Re: EQUINIX INC Form 10-K for the year ended December 31, 2020 Filed on February 19, 2021 File No.000-31293 Dear Mr. Taylor: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Real Estate & Construction