July 14, 2022

VIA EDGAR

Securities and Exchange Commission

Division of Corporate Finance

100 F Street, N.E., Mail Stop 4628

Washington, D.C. 20549

Attention: William Demarest

Mark Rakip

Re: Equinix, Inc.

Form 10-K for Fiscal Year Ended December 31, 2021

Filed February 18, 2022

File No. 001-40205

Mr. Demarest and Mr. Rakip,

On behalf of Equinix, Inc. (“Equinix”, the “Company” or “We”), this letter responds to the comments set forth in your letter dated July 7, 2022. For your convenience, we have repeated the comments in your letter.

1. We note your presentation of the non-GAAP financial measure Adjusted EBITDA presented on an entity-level basis reconciled from Income from operations rather than Net income. As you are providing a performance measure, in future periodic filings please revise to reconcile this measure from consolidated Net income as the most directly comparable measure calculated in accordance with GAAP. Refer to Question 103.02 of the Division's Compliance and Disclosure Interpretations for Non-GAAP Financial Measures.

RESPONSE TO COMMENT 1:

Equinix acknowledges the Staff’s comment and confirms that Equinix will revise its disclosure in future periodic filings to reconcile Adjusted EBITDA to consolidated net income rather than income from operations. We expect that this disclosure will be substantially similar to the reconciliation included in Appendix A, which has been illustratively amended for the Staff’s comment.

2. We note your segment measure of profit or loss is reconciled to Income from operations as presented in your consolidated statements of operations. In future periodic filings, please reconcile your segments' measure of profit or loss to consolidated Income before income taxes. Refer to ASC 280-10-50-30b.

RESPONSE TO COMMENT 2:

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Equinix acknowledges the Staff’s comment and confirms that Equinix will revise its disclosure in future periodic filings to reconcile the segments’ measure of profit or loss to consolidated income before income taxes rather than income from operations. We expect that this disclosure will be substantially similar to the reconciliation included in Appendix B, which has been illustratively amended for the Staff’s comment.

If you have any questions or comments concerning the foregoing, please contact me at (650) 598-6256.

Very truly yours,

/s/ Keith Taylor

Keith Taylor

Chief Financial Officer

cc: Charles Meyers

Brandi Galvin Morandi

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Appendix A:

Form 10-K for the year ended December 31, 2021

Management's Discussion and Analysis of Financial Condition and Results of Operations

Non-GAAP Financial Measures

Adjusted EBITDA, page 65 – Illustratively amended for the Staff’s comment

			Years Ended December 31,
			2021						2020
Net income			$	499,728					$	370,074
Income tax expense			109,224						146,151
Interest income			(2,644)						(8,654)
Interest expense			336,082						406,466
Other (income) expense			50,647						(6,913)
Loss on debt extinguishment			115,125						145,804
Depreciation, amortization, and accretion expense			1,660,524						1,427,010
Stock-based compensation expense			363,774						311,020
Transaction costs			22,769						55,935
Impairment charges			—						7,306
Gain on asset sales			(10,845)						(1,301)
Adjusted EBITDA			$	3,144,384					$	2,852,898

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Appendix B:

Form 10-K for the year ended December 31, 2021

Item 15. Exhibits, Financial Statement Schedules

Financial Statements

Notes to Consolidated Financial Statements

17. Segment Information, page F-61 – Illustratively amended for the Staff’s comment

			Years Ended December 31,
			2021						2020
Adjusted EBITDA:
Americas			$	1,326,460					$	1,186,022
EMEA			1,033,333						974,246
Asia-Pacific			784,591						692,630
Total adjusted EBITDA			3,144,384						2,852,898
Depreciation, amortization and accretion expense			(1,660,524)						(1,427,010)
Stock-based compensation expense			(363,774)						(311,020)
Transaction costs			(22,769)						(55,935)
Impairment charges			—						(7,306)
Gain on asset sales			10,845						1,301
Interest income			2,644						8,654
Interest expense			(336,082)						(406,466)
Other income (expense)			(50,647)						6,913
Loss on debt extinguishment			(115,125)						(145,804)
Income before income taxes			$	608,952					$	516,225